Description

4-Fluoro-3-Methylphenylacetonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a reactive cyano group and a fluorine substituent on a methylated benzene ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors, CNS-active compounds, and other fluorinated active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystal compounds for display technologies.
• Functional Material Development: Employed in creating specialty polymers, dyes, and organic electronic materials that benefit from the unique electronic properties of the fluorine substituent.
• Chemical Research: A valuable reagent for method development in cross-coupling reactions, cyano group transformations, and fluorinated arene chemistry.

Basic Information

Product Name	4-Fluoro-3-Methylphenylacetonitrile
CAS No.	1000548-41-3
Molecular Formula	C9H8FN
Molecular Weight	149.17 g/mol
Synonyms	2-(4-Fluoro-3-methylphenyl)acetonitrile; (4-Fluoro-3-methylphenyl)acetonitrile; 4-Fluoro-3-methylbenzyl cyanide; 4-Fluoro-m-tolylacetonitrile; α-Cyano-4-fluoro-3-methyltoluene; 1000548-41-3; 4-Fluoro-3-methylbenzenacetonitrile
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methylphenylacetonitrile is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP-oriented synthesis and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.