Description

2-Cyano-5-Fluorobenzyl Cyanide is a high-value, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its molecular structure, featuring both a benzylic nitrile and a fluorinated aromatic ring, makes it a critical precursor for constructing complex heterocycles and active pharmaceutical ingredients (APIs). This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated motifs and cyano functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in kinase inhibitors, anticancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials for their unique electronic and physical properties.
• Fluorine Chemistry Building Block: Integral for introducing the 5-fluoro-2-cyanobenzyl moiety into more complex molecular architectures in medicinal and process chemistry.

Basic Information

Item	Details
Product Name	2-Cyano-5-Fluorobenzyl Cyanide
CAS No.	1000540-75-9
Molecular Formula	C9H5FN2
Molecular Weight	160.15 g/mol
Synonyms	5-Fluoro-2-(cyanomethyl)benzonitrile; (5-Fluoro-2-cyanophenyl)acetonitrile; 2-Cyanomethyl-5-fluorobenzonitrile; α-Cyano-5-fluoro-o-tolunitrile; 2-(Cyanomethyl)-5-fluorobenzonitrile; 5-Fluoro-2-cyanobenzyl cyanide; 2-Cyano-5-fluorobenzeneacetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Cyano-5-Fluorobenzyl Cyanide is manufactured and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.