Description

2-(4-Methyl-3-(Trifluoromethyl)Phenyl)Acetonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its trifluoromethyl and methyl substituents. This compound is essential for introducing the lipophilic and electron-withdrawing trifluoromethyl group into target molecules, a key modification in modern pharmaceutical and agrochemical design. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used to construct advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a key building block for electron-transport materials and charge-generating compounds in electronic displays and organic light-emitting diodes.
• Functional Polymer Monomer: Incorporated into specialty polymers to impart unique chemical resistance, thermal stability, or specific optical properties.
• Chemical Research & Development: A versatile reagent for medicinal chemistry, facilitating structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Dye & Pigment Intermediate: Employed in the synthesis of advanced fluorinated colorants with superior lightfastness and chemical resistance.

Basic Information

Product Name	2-(4-Methyl-3-(Trifluoromethyl)Phenyl)Acetonitrile
CAS No.	1000526-63-5
Molecular Formula	C10H8F3N
Molecular Weight	199.17 g/mol
Synonyms	2-[4-Methyl-3-(trifluoromethyl)phenyl]acetonitrile; (4-Methyl-3-trifluoromethylphenyl)acetonitrile; 2-(4-Methyl-3-(trifluoromethyl)phenyl)ethanenitrile; α-Cyano-4-methyl-3-(trifluoromethyl)toluene; 3-Trifluoromethyl-4-methylphenylacetonitrile; 4-Methyl-3-trifluoromethylbenzyl cyanide; 2-(4-Methyl-3-trifluoromethylphenyl)acetonitrile
EINECS	Contact for details

Quality Control

Our production of 2-(4-Methyl-3-(Trifluoromethyl)Phenyl)Acetonitrile adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including HPLC, GC, NMR, and MS for comprehensive characterization. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. Our quality system supports development under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, strong bases, and strong oxidizing agents. The container should be kept tightly sealed in a dry environment to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.