Description

Benzonitrile, 3,6-Difluoro-2-Methyl- (9Ci) is a high-purity fluorinated aromatic nitrile building block, essential for advanced organic synthesis. Its unique difluoro-methyl substitution pattern makes it a critical intermediate for creating complex molecules with tailored electronic and steric properties. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated liquid crystal compounds and electron-transport materials in organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Reagent: A versatile reagent in cross-coupling reactions (e.g., Suzuki, Sonogashira) and cyanation reactions to introduce the benzonitrile moiety into complex structures.
• Material Science Research: Used in academic and industrial R&D for developing new fluorinated aromatic compounds with specific optical or electronic characteristics.

Basic Information

Product Name	Benzonitrile, 3,6-Difluoro-2-Methyl- (9Ci)
CAS No.	198633-77-1
Molecular Formula	C8H5F2N
Molecular Weight	153.13 g/mol
Synonyms	3,6-Difluoro-2-methylbenzonitrile; 2-Methyl-3,6-difluorobenzonitrile; 3,6-Difluoro-o-tolunitrile; 2-Cyano-1,4-difluoro-6-methylbenzene; 1,4-Difluoro-2-cyano-6-methylbenzene; 2-Methyl-3,6-difluorophenyl cyanide; 198633-77-1; 3,6-Difluoro-2-methyl-benzonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 3,6-Difluoro-2-Methyl- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting cGMP and ISO standards for traceability and reliability in your supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.