Description

Fmoc-L-3,4-Difluorophe CAS NO 198560-43-9 is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected α-amino group and a difluorinated phenylalanine side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of fluorinated aromatic residues to modulate the stability, lipophilicity, and biological activity of synthetic peptides. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide-based therapeutics, diagnostics, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the automated synthesis of custom peptides containing fluorinated aromatic amino acids.
• Pharmaceutical Research & Development: For creating peptide drug candidates with enhanced metabolic stability, membrane permeability, and target binding affinity.
• Chemical Biology & Proteomics: Used to synthesize peptide substrates, inhibitors, or activity-based probes to study enzyme function and protein-protein interactions.
• Material Science: Incorporation into peptidomimetics and bio-inspired polymers to engineer materials with specific surface properties.
• Agrochemical Research: Potential use in the design of novel bioactive peptides for crop protection.

Basic Information

Product Name	Fmoc-L-3,4-Difluorophe
CAS No.	198560-43-9
Molecular Formula	C24H19F2NO4
Molecular Weight	423.41 g/mol
Synonyms	Fmoc-3,4-difluoro-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3,4-difluoro-L-phenylalanine; Fmoc-DifluoroPhe-OH; Fmoc-L-(3,4-F2)Phe; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-(3,4-difluorophenyl)propanoic acid; Fmoc-3,4-Dif-Phe-OH; Nα-Fmoc-3,4-difluoro-L-phenylalanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-L-3,4-Difluorophe is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity suitable for demanding research and development applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	-15.0° to -20.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.