Description

Boc-L-3,4-Difluorophe CAS NO 198474-90-7 is a high-purity, protected amino acid derivative featuring a difluorinated phenylalanine side chain. This compound is a critical building block in modern pharmaceutical research and development, enabling the synthesis of complex peptides with enhanced metabolic stability and bioavailability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutic agents, particularly in oncology, metabolic disorders, and CNS-targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the solid-phase and solution-phase synthesis of fluorinated peptide-based drugs.
• Protease Inhibitor Development: Used to incorporate fluorinated phenylalanine residues into peptide sequences to create potent and selective enzyme inhibitors.
• PET Tracer Precursor: Serves as a precursor in the radiochemical synthesis of positron emission tomography (PET) imaging agents targeting specific biological pathways.
• Chemical Biology Research: Employed in the study of protein-protein interactions and enzyme mechanisms by introducing stable fluorine probes into peptide structures.
• Agrochemical Research: Utilized in the discovery of novel bioactive peptides for crop protection agents.
• Custom Peptide Synthesis: An essential reagent for contract research organizations (CROs) and CDMOs producing custom, non-natural amino acid-containing peptides for clients.

Basic Information

Product Name	Boc-L-3,4-Difluorophe
CAS No.	198474-90-7
Molecular Formula	C₁₄H₁₇F₂NO₄
Molecular Weight	301.29 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3,4-difluoro-L-phenylalanine; Boc-3,4-Difluoro-L-Phe-OH; (2S)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-3-(3,4-difluorophenyl)propanoic acid; Boc-DifluoroPhe-OH; N-Boc-3,4-difluoro-L-phenylalanine; tert-Butyloxycarbonyl-3,4-difluoro-L-phenylalanine; BOC-L-3,4-DIFLUOROPHENYLALANINE
EINECS	Contact for details

Quality Control

Our Boc-L-3,4-Difluorophe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identification and impurity profiling. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.