Description

4-Fluoro-2-Trifluoromethylbenzonitrile is a high-value fluorinated aromatic nitrile building block, essential for introducing both fluorine and trifluoromethyl functional groups into complex molecular architectures. Its primary value lies in enabling the synthesis of advanced materials and active pharmaceutical ingredients (APIs) with enhanced metabolic stability, lipophilicity, and bioavailability. This compound is critically needed by R&D and process chemists in the pharmaceutical, agrochemical, and specialty materials industries for developing next-generation products.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitors, anti-cancer agents, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the fluorine and trifluoromethyl groups improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, multi-functional aromatic systems.
• Fluorine Chemistry Research: An important reagent for academic and industrial research exploring new methodologies in fluorination and trifluoromethylation chemistry.

Basic Information

Product Name	4-Fluoro-2-Trifluoromethylbenzonitrile
CAS No.	194853-86-6
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	2-Cyano-5-fluorobenzotrifluoride; 4-Fluoro-2-(trifluoromethyl)benzonitrile; 2-(Trifluoromethyl)-4-fluorobenzonitrile; 4-Fluoro-alpha,alpha,α-trifluoro-o-tolunitrile; Benzonitrile, 4-fluoro-2-(trifluoromethyl)-; 5-Fluoro-2-(trifluoromethyl)benzonitrile; 2-Trifluoromethyl-4-fluorobenzonitrile; 4-Fluoro-2-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Trifluoromethylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.