Description

1H-Cyclopenta[C]Furan-1,3(3Ah)-Dione,5-Fluorotetrahydro-,(3Ar,6As)-Rel- CAS NO 193281-44-6 is a specialized fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its unique fused-ring structure containing both lactone and fluorinated motifs makes it a valuable precursor for creating complex molecular architectures. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-infective therapies.
• Agrochemical Synthesis: Used in the synthesis of advanced, fluorinated active ingredients for crop protection products, leveraging the fluorine atom to enhance biological activity and metabolic stability.
• Material Science Research: Acts as a monomer or precursor for developing novel fluorinated polymers and specialty materials with unique thermal or chemical resistance properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies in asymmetric synthesis and fluorine chemistry.
• Ligand & Catalyst Development: The rigid, functionalized structure is useful for constructing novel chiral ligands and organocatalysts for asymmetric transformations.

Basic Information

Product Name	1H-Cyclopenta[C]Furan-1,3(3Ah)-Dione,5-Fluorotetrahydro-,(3Ar,6As)-Rel-
CAS No.	193281-44-6
Molecular Formula	C7H7FO3
Molecular Weight	158.13 g/mol
Synonyms	rel-(3aR,6aS)-5-Fluorotetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione; (3aR,6aS)-5-Fluorotetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione; 5-Fluorotetrahydro-1H-cyclopenta[c]furan-1,3(3aH)-dione; 5-Fluoro-1H-cyclopenta[c]furan-1,3(3aH)-dione, tetrahydro-, (3aR,6aS)-rel-; Fluorinated Cyclopentafurandione; Fluorolactone Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including HPLC, GC, NMR, and MS to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development needs with custom synthesis and purification services to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.