Description

4-Bromo-2-(trifluoromethyl)benzonitrile is a high-purity, multi-functional aromatic intermediate featuring both bromine and trifluoromethyl substituents on a benzonitrile core. This compound is valued for its unique reactivity profile, enabling its use as a versatile building block in advanced chemical synthesis. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated or fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to construct complex biaryl structures.
• Chemical Research: Employed in academic and industrial R&D for exploring new reaction methodologies and creating compound libraries for screening.

Basic Information

Product Name	4-Bromo-2-(trifluoromethyl)benzonitrile
CAS No.	191165-13-6
Molecular Formula	C8H3BrF3N
Molecular Weight	250.02 g/mol
Synonyms	2-Trifluoromethyl-4-bromobenzonitrile; 4-Bromo-α,α,α-trifluoro-o-tolunitrile; 4-Bromo-2-(trifluoromethyl)benzonitrile; 2-Cyano-5-bromobenzotrifluoride; Benzonitrile, 4-bromo-2-(trifluoromethyl)-; 191165-13-6; 4-Bromo-2-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.