Description

(R)-Bepotastine is the pharmacologically active enantiomer of the antihistamine bepotastine, a selective histamine H1-receptor antagonist. This high-purity chiral intermediate is critical for the synthesis of advanced pharmaceutical formulations targeting allergic conditions. It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in enantiomerically pure active pharmaceutical ingredients (APIs) for ophthalmic and systemic allergy treatments.

Application

• Key chiral building block for the synthesis of the antihistamine drug Bepotastine Besilate.
• Active Pharmaceutical Ingredient (API) intermediate for ophthalmic solutions targeting allergic conjunctivitis.
• Reference standard for analytical method development and quality control in pharmaceutical manufacturing.
• Research chemical for pharmacological studies on histamine H1-receptor antagonism.
• Starting material for the development of novel enantiomerically pure therapeutic agents.
• Process development and scale-up activities in fine chemical and pharmaceutical production.

Basic Information

Product Name	(R)-Bepotastine
CAS No.	190730-41-7
Molecular Formula	C21H25ClN2O3
Molecular Weight	388.89 g/mol
Synonyms	(R)-4-[(S)-(4-Chlorophenyl)(pyridin-2-yl)methoxy]-1-methylpiperidine; (R)-Bepotastine Base; (R)-Bepotastine Free Base; UNII-1V3H2LZ85U; (R)-(-)-Bepotastine; (R)-4-[(S)-p-Chloro-α-2-pyridylbenzyloxy]-1-methylpiperidine; (R)-Ebastine Impurity; (R) enantiomer of Bepotastine
EINECS	Contact for details

Quality Control

Our (R)-Bepotastine CAS NO 190730-41-7 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤1.5%
Single Maximum Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.