Description

Benzonitrile, 2-Amino-4,6-Difluoro- (9Ci) is a high-purity, fluorinated aromatic nitrile derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and sophisticated agrochemicals, where its unique difluoro-substituted aniline core enables precise molecular modifications. It is primarily needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex heterocyclic systems and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Functional Material Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers due to its electron-withdrawing nitrile group and fluorine substituents.
• Dye and Pigment Intermediate: Utilized in the production of high-performance, light-fast dyes and pigments for specialized applications.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.

Basic Information

Product Name	Benzonitrile, 2-Amino-4,6-Difluoro- (9Ci)
CAS No.	190011-84-8
Molecular Formula	C7H4F2N2
Molecular Weight	154.12 g/mol
Synonyms	2-Amino-4,6-difluorobenzonitrile; 4,6-Difluoro-2-aminobenzonitrile; 2-Cyano-3,5-difluoroaniline; 3,5-Difluoro-2-aminobenzonitrile; 2-Amino-4,6-difluorobenzene carbonitrile; Benzonitrile, 2-amino-4,6-difluoro-; 190011-84-8; 4,6-Difluoroanthranilonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 2-Amino-4,6-Difluoro- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP guidelines where applicable to support our clients in pharmaceutical and agrochemical regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong acids, strong bases, and strong oxidizing agents. For long-term storage, consider using an inert atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.