Description

5-Fluoro-2-Methoxybenzonitrile is a versatile and high-purity organic intermediate characterized by its benzonitrile core substituted with fluorine and methoxy groups. This compound is critical for the synthesis of complex molecules, offering precise reactivity for constructing advanced chemical architectures. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the fluorine atom for enhanced biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing specialized aromatic compounds used in electronic displays and organic light-emitting diodes.
• Organic Synthesis & Research: Employed in academic and industrial R&D for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl systems.
• Dye & Pigment Intermediate: Acts as a precursor in the manufacturing of specialized dyes and high-performance pigments.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, tailored intermediates.

Basic Information

Product Name	5-Fluoro-2-Methoxybenzonitrile
CAS No.	189628-38-4
Molecular Formula	C8H6FNO
Molecular Weight	151.14 g/mol
Synonyms	2-Methoxy-5-fluorobenzonitrile; 5-Fluoro-2-methoxybenzonitrile; 5-Fluoro-o-anisonitrile; 2-Cyano-4-fluoroanisole; 4-Flu-oro-2-methoxybenzonitrile; Benzonitrile, 5-fluoro-2-methoxy-; 189628-38-4
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Methoxybenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (GC)	≥97.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.