Description

(R)-Meclizine CAS NO 189298-48-4 is the single enantiomer form of the well-known antihistamine and antiemetic agent, offering a high degree of stereochemical purity for advanced pharmaceutical research and development. This specific chiral form is critical for studying structure-activity relationships, developing novel enantiomerically pure therapeutics, and ensuring precise pharmacological targeting. It is an essential building block for pharmaceutical companies, contract research organizations (CROs), and academic institutions focused on chiral drug discovery, process chemistry, and analytical method development.

Application

• Chiral Pharmaceutical Intermediate: Serves as a key starting material or intermediate in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• Pharmacological Research: Used in preclinical studies to investigate the specific biological activity, metabolism, and toxicity profile of the (R)-enantiomer.
• Analytical Standard: Acts as a high-purity reference standard for HPLC, LC-MS, or chiral separation methods to quantify enantiomeric purity.
• Process Development & Optimization: Employed in developing and scaling up asymmetric synthesis routes or chiral separation processes.
• Regulatory Submissions: Provides the necessary characterized material for inclusion in regulatory filings (e.g., FDA, EMA) for new drug applications.

Basic Information

Product Name	(R)-Meclizine
CAS No.	189298-48-4
Molecular Formula	C25H27ClN2
Molecular Weight	390.95 g/mol
Synonyms	(R)-Meclizine; (R)-1-[(4-Chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine; (R)-1-(p-Chloro-α-phenylbenzyl)-4-(m-methylbenzyl)piperazine; (R)-Meclizine Hydrochloride (salt form); Dexmeclizine; (R)-Enantiomer of Meclizine; (R)-Postafen; (R)-Bonine
EINECS	Contact for details

Quality Control

Every batch of (R)-Meclizine is manufactured and tested under strict quality management systems to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for chiral purity, chemical purity, and related substances analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.