Description

Angiogenesis Inhibitor CAS NO 186611-44-9 is a potent, small-molecule compound specifically designed to inhibit the formation of new blood vessels, a critical process in various pathological conditions. This targeted mechanism of action makes it a valuable research tool and a key candidate in therapeutic development pipelines. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, ophthalmology, and other angiogenesis-dependent diseases.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) in the preclinical and clinical development of novel anti-cancer therapies.
• Oncology Studies: Used extensively in in vitro and in vivo models to study tumor growth, metastasis, and the efficacy of combination therapies targeting vascular endothelial growth factor (VEGF) pathways.
• Ophthalmic Disease Research: Applied in research for conditions like age-related macular degeneration (AMD) and diabetic retinopathy, where abnormal blood vessel growth is a primary concern.
• Biochemical Assay Development: Employed as a precise inhibitor in high-throughput screening (HTS) assays to identify and validate new drug targets related to angiogenesis.
• Academic & Institutional Research: Supports fundamental biological research into the mechanisms of angiogenesis, cell signaling, and endothelial cell biology.

Basic Information

Product Name	Angiogenesis Inhibitor
CAS No.	186611-44-9
Molecular Formula	C₁₉H₁₅N₅O₃
Molecular Weight	361.35 g/mol
Synonyms	SU5416; Semaxanib; VEGF Receptor 2 Inhibitor; 3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinone; ZD-6474 analog; Tyrosine Kinase Inhibitor; Angiogenesis Blocker; VEGFR2/Flk-1 Inhibitor
EINECS	Contact for details

Quality Control

Our Angiogenesis Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.