Description

Benzonitrile, 3,4-Difluoro-5-Hydroxy- (9Ci) is a high-value, multi-functional aromatic nitrile building block characterized by its unique substitution pattern of fluorine atoms and a hydroxyl group. This CAS 186590-38-5 compound is critical for advanced organic synthesis, enabling the introduction of a difluorohydroxybenzene moiety into target molecules. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors for the creation of novel active ingredients, where its specific fluorine chemistry can modulate biological activity, metabolic stability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the difluoro and hydroxy groups contribute to enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic materials, contributing to improved thermal stability and electro-optical properties.
• Polymer Chemistry: Acts as a monomer or modifying agent for creating specialty polymers with specific chemical resistance or surface properties.
• Chemical Research & Development: Employed in academic and industrial labs for methodology development, catalysis studies, and the exploration of novel fluorination reactions.
• Dye & Pigment Intermediate: Utilized in the synthesis of complex, high-performance colorants requiring specific halogenated aromatic structures.

Basic Information

Product Name	Benzonitrile, 3,4-Difluoro-5-Hydroxy- (9Ci)
CAS No.	186590-38-5
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	3,4-Difluoro-5-hydroxybenzonitrile; 5-Cyano-2,3-difluorophenol; 2,3-Difluoro-5-hydroxybenzonitrile; 5-Hydroxy-3,4-difluorobenzonitrile; Phenol, 5-cyano-2,3-difluoro-; 186590-38-5; 3,4-Difluoro-5-hydroxy-benzonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 3,4-Difluoro-5-Hydroxy- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong acids/bases and oxidizing agents. For long-term storage, consider using an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.