Description

4,5-Difluoro-2-Hydroxybenzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines a nitrile group with hydroxyl and fluorine substituents, enabling precise modifications in complex molecule construction. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the synthesis of advanced herbicides and fungicides, where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated liquid crystal molecules and organic light-emitting diode (OLED) materials.
• Polymer Chemistry: Employed in the synthesis of specialty polymers and high-performance resins with tailored properties.
• Chemical Research & Development: A valuable reagent for method development and exploring new fluorination and functionalization reactions in academic and industrial R&D labs.
• Fluorinated Dye Intermediate: Used in the production of specialized dyes and pigments with enhanced light-fastness and color properties.

Basic Information

Product Name	4,5-Difluoro-2-Hydroxybenzonitrile
CAS No.	186590-36-3
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	2-Hydroxy-4,5-difluorobenzonitrile; 4,5-Difluoro-2-hydroxybenzonitrile; 4,5-Difluoro-2-hydroxybenzenecarbonitrile; 2-Cyano-4,5-difluorophenol; 4,5-Difluorosalicylonitrile; 2-Hydroxy-4,5-difluorobenzene-1-carbonitrile; 186590-36-3
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Hydroxybenzonitrile is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.