Description

Benzonitrile, 3,4-Difluoro-2-Hydroxy- (9Ci) is a high-purity fluorinated aromatic nitrile building block, distinguished by its unique combination of functional groups. This compound is critical for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, where its specific substitution pattern enables precise molecular modifications.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the difluoro-hydroxy motif can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials, contributing to improved performance and durability.
• Organic Ligand & Catalyst Development: Employed in the creation of specialized ligands for metal-catalyzed cross-coupling reactions, a cornerstone of modern synthetic methodology.
• Advanced Polymer Chemistry: Acts as a monomer or modifier in the synthesis of high-performance, specialty polymers with tailored thermal and chemical resistance.

Basic Information

Product Name	Benzonitrile, 3,4-Difluoro-2-Hydroxy- (9Ci)
CAS No.	186590-34-1
Molecular Formula	C7H3F2NO
Molecular Weight	155.10 g/mol
Synonyms	2-Hydroxy-3,4-difluorobenzonitrile; 3,4-Difluoro-2-hydroxybenzonitrile; 2-Cyano-6,7-difluorophenol; 6,7-Difluoro-2-hydroxybenzonitrile; 3,4-Difluoro-2-hydroxybenzenecarbonitrile; 2-Hydroxy-3,4-difluorophenyl cyanide; 186590-34-1 (CAS)
EINECS	Contact for details

Quality Control

Every batch of Benzonitrile, 3,4-Difluoro-2-Hydroxy- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the exacting standards required for research and scale-up activities. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area%)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.