Description

2,3-Difluoro-6-(trifluoromethyl)benzonitrile is a high-value fluorinated aromatic nitrile building block. This compound is essential for introducing multiple fluorine atoms and a versatile nitrile functional group into complex molecular architectures, enabling precise tuning of electronic properties, lipophilicity, and metabolic stability. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs where fluorine substitution is critical.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), where its structure aids in charge transport and stability.
• Polymer & Material Science: Employed as a monomer or modifier to create specialty polymers with unique surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: The nitrile and halogen substituents make it a versatile substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to build complex biaryl systems.
• Fluorine Chemistry Research: A valuable standard and starting material in academic and industrial R&D focused on exploring new fluorination methodologies and structure-activity relationships (SAR).

Basic Information

Product Name	2,3-Difluoro-6-(trifluoromethyl)benzonitrile
CAS No.	186517-05-5
Molecular Formula	C8H2F5N
Molecular Weight	207.10 g/mol
Synonyms	2,3-Difluoro-6-(trifluoromethyl)benzonitrile; 2,3-Difluoro-α,α,α-trifluoro-p-tolunitrile; 6-Cyano-2,3-difluorobenzotrifluoride; 2,3-Difluoro-α,α,α-trifluoro-4-methylbenzonitrile; Benzonitrile, 2,3-difluoro-6-(trifluoromethyl)-; 186517-05-5; 2,3-Difluoro-6-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-6-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with REACH and other relevant global regulatory frameworks for industrial and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.