Description

1-Bromo-2-Fluoro-4-Nitrobenzene is a versatile halogenated nitroaromatic compound that serves as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it a valuable precursor for introducing both bromine and fluorine functionalities into complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, enabling the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing electronic materials used in displays and organic light-emitting diodes.
• Polymer Modification: Employed to introduce halogenated aromatic units into polymer backbones to alter thermal and optical properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Dye & Pigment Industry: Intermediate in the synthesis of specialized nitroaromatic dyes and pigments.
• Chemical Research & Development: A valuable reagent for exploring new reaction pathways and synthesizing novel fluorinated aromatic compounds in academic and industrial R&D.

Basic Information

Product Name	1-Bromo-2-Fluoro-4-Nitrobenzene
CAS No.	185331-69-5
Molecular Formula	C6H3BrFNO2
Molecular Weight	220.00 g/mol
Synonyms	2-Fluoro-4-nitro-1-bromobenzene; 4-Nitro-2-fluorobromobenzene; 1-Bromo-2-fluoro-4-nitro-benzene; 2-Fluoro-4-nitrobromobenzene; Benzene, 1-bromo-2-fluoro-4-nitro-; 4-Nitro-2-fluorophenyl bromide; 2-Fluoro-4-nitrophenyl bromide; 185331-69-5
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-4-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, guaranteeing consistency and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent decomposition.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	48 - 52 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.