Description

Abarelix CAS NO 183552-38-7 is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) that functions as a potent GnRH antagonist. This compound is of significant commercial and therapeutic importance due to its ability to rapidly suppress gonadotropin and sex hormone secretion without causing an initial flare-up effect. It is primarily required by the pharmaceutical industry for the development and manufacturing of advanced hormonal therapies, particularly for the treatment of hormone-sensitive conditions such as advanced prostate cancer.

Application

• Active Pharmaceutical Ingredient (API): Core component in the formulation of injectable hormonal therapies.
• Oncology Research: Used in preclinical and clinical studies targeting androgen-dependent cancers.
• Endocrinology: Research tool for studying the hypothalamic-pituitary-gonadal axis and hormone regulation mechanisms.
• Pharmaceutical Intermediates: Serves as a key synthetic intermediate for further chemical modification and drug development.
• Reference Standard: High-purity material for use as a calibration standard in analytical laboratories for quality control and method validation.

Basic Information

Product Name	Abarelix
CAS No.	183552-38-7
Molecular Formula	C72H95ClN14O14
Molecular Weight	1416.04 g/mol
Synonyms	Abarelix; PPI-149; R-3827; Ac-D2Nal-D4Cpa-D3Pal-Ser-N-MeTyr-DAsn-Leu-Lys(iPr)-Pro-DAla-NH2; Gonadotropin-Releasing Hormone Antagonist (GnRH Antagonist); Plenaxis (brand name)
EINECS	Contact for details

Quality Control

Our Abarelix is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for pharmaceutical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant Good Manufacturing Practice (GMP) principles and can provide material that meets specifications for use as a pharmaceutical reference standard or API intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular mass
Assay (HPLC)	≥98.0%
Purity (HPLC, Total)	≥99.0%
Single Unknown Impurity (HPLC)	≤0.5%
Water Content (KF)	≤5.0%
Residue on Ignition	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.