Description

2-Chloro-4-Fluoro-5-Nitrobenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and nitro substituents on a benzonitrile core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring a halogenated aromatic scaffold.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the nitro and halogen groups are crucial for bioactivity.
• Material Science Research: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Dye and Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and pigments where color fastness and specific properties are required.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination, enabling rapid diversification.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Nitrobenzonitrile
CAS No.	183325-39-5
Molecular Formula	C7H2ClFN2O2
Molecular Weight	200.55 g/mol
Synonyms	5-Nitro-2-chloro-4-fluorobenzonitrile; 2-Chloro-4-fluoro-5-nitrobenzenecarbonitrile; Benzonitrile, 2-chloro-4-fluoro-5-nitro-; 4-Fluoro-2-chloro-5-nitrobenzonitrile; 2-Chloro-4-fluoro-5-nitro-benzonitrile; 183325-39-5; 5-Nitro-2-chloro-4-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the stringent requirements of fine chemical synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent quality for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.