Description

(R)-Isothipendyl CAS NO 183287-73-2 is a high-purity enantiomer of the classical antihistamine and anticholinergic compound, Isothipendyl. This specific stereoisomer is of significant interest for advanced pharmaceutical research and development, particularly in the study of receptor selectivity and the creation of novel therapeutic agents. It serves as a critical chiral building block and reference standard for researchers and manufacturers in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and synthesis of new chemical entities (NCEs) with potential antihistaminic or anticholinergic activity.
• Reference Standard: Used as a high-purity analytical standard in method development and validation for quality control (QC) and research & development (R&D) laboratories.
• Metabolite Studies: Employed in pharmacological and toxicological research to investigate the metabolism, pharmacokinetics, and stereoselective effects of Isothipendyl and related compounds.
• Biochemical Research: Utilized as a tool compound in receptor binding assays and studies targeting histamine H1 receptors and muscarinic acetylcholine receptors.
• Process Chemistry: Acts as a starting material or intermediate in the development and scale-up of enantioselective synthetic routes.

Basic Information

Product Name	(R)-Isothipendyl
CAS No.	183287-73-2
Molecular Formula	C₁₆H₁₉N₃S
Molecular Weight	285.41 g/mol
Synonyms	(R)-Isothipendyl; (R)-9-(2-Dimethylaminoethyl)-10-thia-1,9-diazatricyclo[6.4.0.0²,⁶]dodeca-2(6),3,7,11-tetraene; (R)-N,N-Dimethyl-2-(10-thia-1,9-diazatricyclo[6.4.0.0²,⁶]dodeca-2(6),3,7,11-tetraen-9-yl)ethanamine; (R)-Isothipendyl Hydrochloride (salt form); Dexisothipendyl; (R)-Azaphenothiazine derivative
EINECS	Contact for details

Quality Control

Our (R)-Isothipendyl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) providing identity, purity, and impurity profile is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.