Description

2H-Cyclopenta[B]Furan-2-One,3,3-Difluoro-3,3A,6,6A-Tetrahydro-,(3Ar-Cis)- is a high-value, stereochemically defined fluorinated heterocyclic building block. This compound is critical for introducing the difluoromethylene moiety into complex molecular architectures, a key strategy in modern medicinal chemistry for modulating physicochemical properties. It serves as a versatile synthetic intermediate for researchers and process chemists in the pharmaceutical and agrochemical industries, enabling the development of novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where fluorine substitution is beneficial.
• Material Science Precursor: Serves as a monomer or precursor for specialty polymers and advanced materials with unique properties.
• Fluorine Chemistry Research: An essential reagent for academic and industrial R&D exploring new fluorination methodologies and organofluorine compounds.
• Ligand and Catalyst Development: Used to construct complex, fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2H-Cyclopenta[B]Furan-2-One,3,3-Difluoro-3,3A,6,6A-Tetrahydro-,(3Ar-Cis)-
CAS No.	182932-03-2
Molecular Formula	C7H6F2O2
Molecular Weight	160.12 g/mol
Synonyms	(3aR-cis)-3,3-Difluoro-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-2-one; 3,3-Difluoro-3,3a,6,6a-tetrahydro-2H-cyclopenta[b]furan-2-one, (3aR-cis)-; cis-3,3-Difluorohexahydro-2H-cyclopenta[b]furan-2-one; Difluorinated Cyclopentafuranone; Fluorinated Lactone Building Block
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized using advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects with specifications tailored to meet cGMP and ICH guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.