Description

4-Fluoro-2-Nitrobenzotrifluoride is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring both nitro and trifluoromethyl substituents on a fluorinated benzene ring, makes it a critical building block for creating complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic cores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Manufacturing: Acts as an intermediate for synthesizing complex, high-performance dyes and pigments with improved lightfastness and color properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) due to the presence of the reactive nitro and fluorine groups, enabling rapid diversification of chemical libraries.

Basic Information

Item	Details
Product Name	4-Fluoro-2-Nitrobenzotrifluoride
CAS No.	182289-81-2
Molecular Formula	C7H3F4NO2
Molecular Weight	209.10 g/mol
Synonyms	2-Nitro-4-fluorobenzotrifluoride; 4-Fluoro-2-nitro-α,α,α-trifluorotoluene; 1-Fluoro-2-nitro-4-(trifluoromethyl)benzene; 4-Fluoro-α,α,α-trifluoro-2-nitrotoluene; Benzene, 1-fluoro-2-nitro-4-(trifluoromethyl)-; 4-Fluoro-2-nitrobenzyl trifluoride; 4-Fluoro-2-nitro-α,α,α-trifluoromethylbenzene
EINECS	Contact for details

Quality Control

Our 4-Fluoro-2-Nitrobenzotrifluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.