Description

3-Cyano-4-Fluorobenzyl Bromide is a versatile and high-purity fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive bromomethyl group and a cyano substituent on a fluorinated aromatic ring, makes it indispensable for introducing functionalized benzyl motifs. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, such as active pharmaceutical ingredients (APIs) and advanced intermediates. We ensure a reliable supply of this high-value intermediate with consistent quality to support your R&D and scale-up projects.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used to construct advanced intermediates for herbicides, fungicides, and pesticides requiring fluorinated aromatic systems.
• Ligand and Material Science: Building block for creating specialized ligands for catalysis and functional monomers for advanced polymers.
• Cross-Coupling Reactions: Serves as an electrophilic partner in various palladium-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Derivatization Agent: Utilized for the benzylation of nucleophiles such as amines, alcohols, and carboxylic acids in medicinal chemistry.
• Fluorine Chemistry Research: Essential reagent for studying structure-activity relationships (SAR) by introducing both fluorine and a versatile handle for further functionalization.

Basic Information

Item	Details
Product Name	3-Cyano-4-Fluorobenzyl Bromide
CAS No.	180302-35-6
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	4-Fluoro-3-cyanobenzyl Bromide; (4-Fluoro-3-cyanophenyl)methyl Bromide; 1-(Bromomethyl)-4-fluoro-3-cyanobenzene; α-Bromo-4-fluoro-3-cyanotoluene; 3-Cyano-4-fluorobenzylbromide; 4-Fluoro-3-cyanobenzylbromide; 3-Cyano-4-fluoro-benzyl bromide
EINECS	Contact for details

Quality Control

Every batch of 3-Cyano-4-Fluorobenzyl Bromide is manufactured and tested under strict quality management protocols to ensure it meets the high-purity standards required for sensitive synthetic applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is available upon request and accompanies each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay	≥ 95.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.