Description

1-(3-Fluorophenyl)Cyclobutanecarbonitrile is a versatile fluorinated organic building block of significant interest in advanced chemical synthesis. Its core value lies in the strategic combination of a cyclobutane ring and a fluorinated aromatic system, which is crucial for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing conformational constraint and fluorine atoms to improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the design and production of advanced pesticides and herbicides, where the fluorophenyl moiety can enhance biological activity and environmental persistence profiles.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis or as a framework for organocatalysts.
• Material Science Research: Employed in the synthesis of monomers or functional units for advanced polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probes: Utilized as a building block for fluorescent tags or molecular probes used in biochemical and cellular imaging studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(3-Fluorophenyl)Cyclobutanecarbonitrile
CAS No.	179411-83-7
Molecular Formula	C11H10FN
Molecular Weight	175.20 g/mol
Synonyms	3-Fluorophenylcyclobutanecarbonitrile; 1-(3-Fluorophenyl)cyclobutanecarbonitrile; Cyclobutanecarbonitrile, 1-(3-fluorophenyl)-; 1-(3-Fluorophenyl)cyclobane-1-carbonitrile; (3-Fluorophenyl)cyclobutanecarbonitrile; m-Fluorophenylcyclobutanecarbonitrile
EINECS	Contact for details

Quality Control

Our 1-(3-Fluorophenyl)Cyclobutanecarbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.