Description

2,4-Difluoro-5-Methoxynitrobenzene is a high-purity fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a valuable building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic rings for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the difluoro and nitro groups contribute to biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex fluorinated dyes and organic pigments.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating biaryl structures.
• Organic Synthesis Building Block: Utilized in academic and industrial R&D for nucleophilic aromatic substitution and other functional group transformations.

Basic Information

Product Name	2,4-Difluoro-5-Methoxynitrobenzene
CAS No.	179011-39-3
Molecular Formula	C7H5F2NO3
Molecular Weight	189.12 g/mol
Synonyms	1,4-Difluoro-2-methoxy-5-nitrobenzene; 5-Methoxy-2,4-difluoronitrobenzene; 2,4-Difluoro-5-nitroanisole; 2-Methoxy-4,6-difluoronitrobenzene; Benzene, 2,4-difluoro-5-methoxy-1-nitro-; 5-Nitro-2,4-difluoroanisole
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Methoxynitrobenzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets the high standards required for sensitive synthetic applications. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming identity, purity, and impurity profiles. Specifications are designed to meet the needs of GMP-aligned pharmaceutical development and other critical industrial processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.