Description

2-(4-(Trifluoromethyl)-2,5-Dimethoxyphenyl)Acetonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its trifluoromethyl and dimethoxy substituents. This compound is essential for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of molecules targeting central nervous system (CNS) disorders, anti-inflammatory agents, and antiviral drugs.
• Agrochemical Synthesis: Serves as a critical precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Used in the development of novel organic electronic materials, where its aromatic core and substituents influence electronic properties and molecular alignment.
• Fluorinated Compound Library Synthesis: A valuable reagent for medicinal chemistry and discovery chemistry labs building diverse compound libraries to explore structure-activity relationships (SAR).
• Cross-Coupling Reactions: The nitrile and halogen-substituted aromatic ring (if further functionalized) make it a suitable substrate for palladium-catalyzed cross-coupling reactions like Suzuki, Stille, or Buchwald-Hartwig amination.
• Dye & Pigment Intermediate: Can be utilized in the synthesis of specialized dyes and pigments, where the methoxy and trifluoromethyl groups modify color and solubility properties.

Basic Information

Product Name	2-(4-(Trifluoromethyl)-2,5-Dimethoxyphenyl)Acetonitrile
CAS No.	178896-77-0
Molecular Formula	C11H10F3NO2
Molecular Weight	245.20 g/mol
Synonyms	[4-(Trifluoromethyl)-2,5-dimethoxyphenyl]acetonitrile; 2,5-Dimethoxy-4-(trifluoromethyl)benzyl cyanide; (4-Trifluoromethyl-2,5-dimethoxyphenyl)acetonitrile; α-(4-Trifluoromethyl-2,5-dimethoxyphenyl)acetonitrile; 2-(4-Trifluoromethyl-2,5-dimethoxyphenyl)acetonitrile; 4-(Trifluoromethyl)-2,5-dimethoxybenzeneacetonitrile; 2,5-Dimethoxy-α-((trifluoromethyl)phenyl)acetonitrile (isomer); CAS 178896-77-0
EINECS	Contact for details

Quality Control

Our 2-(4-(Trifluoromethyl)-2,5-Dimethoxyphenyl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, the container should be opaque or stored in darkness.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.