Description

Cyclopropanecarboxylic Acid, 2-Fluoro-, Butyl Ester, (1S,2S)- (9Ci) is a high-purity, stereochemically defined fluorinated cyclopropane derivative. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the introduction of the pharmacologically privileged cyclopropane scaffold with precise stereocontrol. It is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced metabolic stability and binding affinity.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated drug candidates, including protease inhibitors, kinase inhibitors, and CNS-active compounds.
• Agrochemical Research: Used in developing novel pesticides and herbicides where the fluorocyclopropane moiety can improve biological activity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Potential monomer or modifier for creating specialty polymers with unique fluorinated properties.
• Chemical Biology: Employed as a molecular probe to study enzyme mechanisms and protein-ligand interactions due to its fluorine label and rigid structure.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Fluoro-, Butyl Ester, (1S,2S)- (9Ci)
CAS No.	177933-52-7
Molecular Formula	C8H13FO2
Molecular Weight	160.18 g/mol
Synonyms	(1S,2S)-2-Fluorocyclopropanecarboxylic Acid Butyl Ester; Butyl (1S,2S)-2-Fluorocyclopropanecarboxylate; (1S,2S)-2-Fluorocyclopropanecarboxylic Acid n-Butyl Ester; trans-2-Fluorocyclopropanecarboxylic Acid Butyl Ester; (1S,2S)-rel-2-Fluorocyclopropanecarboxylic Acid Butyl Ester; Fluorocyclopropanecarboxylate Ester; BFCB Ester
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Fluoro-, Butyl Ester, (1S,2S)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for demanding R&D and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider maintaining under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.