Description

(E)-4-Hydroxy Toremifene is a high-purity, non-steroidal selective estrogen receptor modulator (SERM) and a key active metabolite of the pharmaceutical agent Toremifene. This compound is of significant value for pharmaceutical research and development, serving as a critical reference standard and a potential synthetic intermediate. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in oncology research, drug metabolism studies, and the development of novel hormone-based therapies.

Application

• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis of Toremifene and its metabolites in drug substance and finished product testing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthetic pathway for Toremifene citrate and related SERM compounds.
• Biochemical Research: Employed in in vitro studies to investigate estrogen receptor binding affinity, antagonist activity, and downstream cellular signaling pathways.
• Metabolite Identification & Pharmacokinetics: Essential for studying the absorption, distribution, metabolism, and excretion (ADME) profile of Toremifene in preclinical and clinical research.
• Quality Control & Method Development: Critical for developing and validating analytical methods (e.g., HPLC, LC-MS) in pharmaceutical quality control laboratories.

Basic Information

Product Name	(E)-4-Hydroxy Toremifene
CAS No.	177748-22-0
Molecular Formula	C₂₆H₂₈ClNO₂
Molecular Weight	422.0 g/mol
Synonyms	4-Hydroxytoremifene; (E)-4-[4-[(Z)-4-Chloro-1,2-diphenyl-1-buten-1-yl]phenoxy]-N,N-dimethylbutan-1-amine; FC-1271a; Toremifene Metabolite; Z-4-Hydroxy Toremifene (incorrect but common); 4-OH-Toremifene
EINECS	Contact for details

Quality Control

Our (E)-4-Hydroxy Toremifene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical reference standards and intermediates. A detailed Certificate of Analysis (COA) providing HPLC purity, related substance profiles, and other critical parameters is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.