Description

1-Fluoro-2-Iodo-4-Nitrobenzene is a halogenated nitrobenzene derivative that serves as a versatile and valuable building block in advanced organic synthesis. Its unique combination of fluorine, iodine, and nitro substituents on the aromatic ring makes it a critical intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by research chemists and process development scientists for applications in cross-coupling reactions, nucleophilic aromatic substitution, and the synthesis of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those requiring halogenated aromatic scaffolds for bioactivity or further functionalization.
• Agrochemical Synthesis: Used in the development of herbicides, fungicides, and insecticides where the nitro and halogen groups contribute to the desired biological activity.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Sonogashira couplings to form biaryl structures.
• Nucleophilic Aromatic Substitution (SNAr): The fluorine and nitro groups activate the ring for substitution by various nucleophiles, enabling diverse chemical transformations.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	1-Fluoro-2-Iodo-4-Nitrobenzene
CAS No.	177363-10-9
Molecular Formula	C6H3FINO2
Molecular Weight	266.99 g/mol
Synonyms	2-Fluoro-1-Iodo-4-Nitrobenzene; 4-Nitro-2-Fluoroiodobenzene; 2-Fluoro-4-Nitroiodobenzene; 1-Iodo-2-Fluoro-4-Nitrobenzene; 2-Fluoro-1-iodo-4-nitro-benzene; Benzene, 1-fluoro-2-iodo-4-nitro-; (2-Fluoro-4-nitrophenyl)iodide
EINECS	Contact for details

Quality Control

Our 1-Fluoro-2-Iodo-4-Nitrobenzene is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.