Description

2-[4-Nitro-3-(Trifluoromethyl)Phenyl]Acetonitrile is a high-value, multi-functional aromatic nitrile building block characterized by its nitro and trifluoromethyl substituents. This compound is essential for advanced organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of biologically active molecules, including potential kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in the research and development of new herbicides and pesticides, leveraging the bioactivity of the trifluoromethyl and nitro groups.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of advanced polymers and liquid crystals.
• Dye and Pigment Intermediate: Employed in the synthesis of specialized dyes and pigments due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for creating complex biaryl systems.
• Chemical Library Development: A valuable scaffold for generating diverse compound libraries in high-throughput screening and medicinal chemistry programs.

Basic Information

Product Name	2-[4-Nitro-3-(Trifluoromethyl)Phenyl]Acetonitrile
CAS No.	176689-23-9
Molecular Formula	C9H5F3N2O2
Molecular Weight	230.15 g/mol
Synonyms	4-Nitro-3-(trifluoromethyl)benzyl cyanide; 2-(4-Nitro-3-(trifluoromethyl)phenyl)acetonitrile; [4-Nitro-3-(trifluoromethyl)phenyl]acetonitrile; α-(4-Nitro-3-trifluoromethylphenyl)acetonitrile; (4-Nitro-3-trifluoromethylphenyl)acetonitrile; 4-Nitro-α-(trifluoromethyl)benzeneacetonitrile; 2-(4-Nitro-3-trifluoromethylphenyl)ethanenitrile
EINECS	Contact for details

Quality Control

Our 2-[4-Nitro-3-(Trifluoromethyl)Phenyl]Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases, strong oxidizing agents, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.