Description

Benzonitrile, 4-Ethynyl-2,3-Difluoro- (9Ci) is a high-purity, multi-functional aromatic nitrile building block featuring both cyano and ethynyl groups on a difluorinated benzene ring. This compound is valued for its role as a key intermediate in advanced organic synthesis, enabling the construction of complex molecular architectures. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and materials science industries for applications in drug discovery, ligand synthesis, and the development of specialty polymers.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and oncology drug discovery programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and pesticides, leveraging its difluoro and ethynyl motifs.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research Reagent: Employed in academic and industrial R&D for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira coupling) and click chemistry.
• Ligand Synthesis: Utilized for creating novel ligands for catalysis and metal-organic frameworks (MOFs) due to its nitrile and alkyne functionalities.

Basic Information

Product Name	Benzonitrile, 4-Ethynyl-2,3-Difluoro- (9Ci)
CAS No.	175283-25-7
Molecular Formula	C9H3F2N
Molecular Weight	163.13 g/mol
Synonyms	4-Ethynyl-2,3-difluorobenzonitrile; 2,3-Difluoro-4-ethynylbenzonitrile; 4-Ethynyl-2,3-difluorobenzonitrile (9CI); 175283-25-7; Benzonitrile, 4-ethynyl-2,3-difluoro-; 2,3-Difluoro-4-(ethynyl)benzonitrile
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Ethynyl-2,3-Difluoro- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.