Description

4-Amino-3-(Trifluoromethoxy)Benzonitrile is a high-purity, multi-functional aromatic intermediate featuring both an amino and a nitrile group on a trifluoromethoxy-substituted benzene ring. This unique molecular structure makes it a critical building block for synthesizing advanced pharmaceutical compounds and agrochemicals, particularly those requiring enhanced metabolic stability and lipophilicity. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors, anti-cancer agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for electron-transport materials and charge-transport layers in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modifier: Incorporated into specialty polymers to enhance thermal stability, chemical resistance, and specific functional properties.
• Dye & Pigment Intermediate: Utilized in the production of high-performance, light-fast dyes and pigments for industrial applications.
• Research & Development: A valuable compound for medicinal chemistry and material science research in academic and industrial laboratories.

Basic Information

Product Name	4-Amino-3-(Trifluoromethoxy)Benzonitrile
CAS No.	175278-23-6
Molecular Formula	C8H5F3N2O
Molecular Weight	202.13 g/mol
Synonyms	3-(Trifluoromethoxy)-4-aminobenzonitrile; 4-Cyano-2-(trifluoromethoxy)aniline; 2-Amino-5-cyano-1-(trifluoromethoxy)benzene; 4-Amino-α,α,α-trifluoro-m-tolunitrile; Benzonitrile, 4-amino-3-(trifluoromethoxy)-; 4-Amino-3-trifluoromethoxybenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-3-(Trifluoromethoxy)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be handled under appropriate conditions to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.