Description

3-(Trifluoromethyl)Benzylsulfonyl Acetonitrile is a specialized fluorinated organic intermediate featuring a reactive acetonitrile moiety linked to a benzylsulfonyl group. This compound matters for its role as a versatile building block in the synthesis of complex molecules, particularly in the development of pharmaceuticals and agrochemicals where the trifluoromethyl group is prized for its ability to modulate biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Material Science Research: Serves as a precursor for developing novel polymers, liquid crystals, and electronic materials with specific fluorinated properties.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes (ABPs) and other chemical tools for studying enzyme function and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up services for clients in regulated industries.

Basic Information

Product Name	3-(Trifluoromethyl)Benzylsulfonyl Acetonitrile
CAS No.	175276-81-0
Molecular Formula	C10H8F3NO2S
Molecular Weight	263.23 g/mol
Synonyms	α-[(3-Trifluoromethylphenyl)methylsulfonyl]acetonitrile; (3-Trifluoromethylbenzyl)sulfonylacetonitrile; Acetonitrile, [[(3-(trifluoromethyl)phenyl)methyl]sulfonyl]-; 2-(((3-(Trifluoromethyl)benzyl)sulfonyl)acetonitrile; 3-(Trifluoromethyl)benzylsulfonylacetonitrile; α-((3-(Trifluoromethyl)benzyl)sulfonyl)acetonitrile
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)Benzylsulfonyl Acetonitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.