Description

5-Methyl-2-(Trifluoromethyl)Furo-3-Ylacetonitrile is a high-value, specialized heterocyclic building block featuring a fused furan ring system substituted with a trifluoromethyl group and an acetonitrile moiety. This compound is critical for introducing unique steric and electronic properties into target molecules, enabling the development of advanced materials and bioactive compounds with enhanced performance characteristics. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material science industries for applications in medicinal chemistry, crop protection, and functional polymer synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel drug candidates, particularly for incorporating the metabolically stable trifluoromethyl group and the versatile nitrile functionality into heterocyclic scaffolds.
• Agrochemical Active Ingredient Development: Used in research to create new herbicides, fungicides, and insecticides, where the furan and trifluoromethyl groups can contribute to improved biological activity and environmental profile.
• Advanced Material Synthesis: Acts as a monomer or precursor for specialty polymers, liquid crystals, and organic electronic materials due to its rigid fused-ring structure and potential for further functionalization.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems, leveraging the nitrile group for click chemistry or bioconjugation.
• Fine Chemical and Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	5-Methyl-2-(Trifluoromethyl)Furo-3-Ylacetonitrile
CAS No.	175276-72-9
Molecular Formula	C9H6F3NO
Molecular Weight	201.15 g/mol
Synonyms	5-Methyl-2-(trifluoromethyl)-3-furanacetonitrile; 2-(5-Methyl-2-(trifluoromethyl)furan-3-yl)acetonitrile; 3-Furanacetonitrile, 5-methyl-2-(trifluoromethyl)-; 5-Methyl-2-trifluoromethylfuran-3-acetonitrile; (5-Methyl-2-(trifluoromethyl)furan-3-yl)acetonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Methyl-2-(Trifluoromethyl)Furo-3-Ylacetonitrile is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency meet the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.