Description

2-Fluoro-6-(4-Chlorophenylthio)Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique fluorinated benzonitrile core. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need it to develop next-generation drugs, leveraging its specific fluorine and sulfur-containing structure for enhanced bioactivity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new drug candidates, especially in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Research: Used in developing novel pesticides and herbicides, where the fluorine atom and aromatic system contribute to biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or precursor in the development of specialty polymers and advanced organic electronic materials.
• Ligand Synthesis: Utilized in organometallic chemistry for the preparation of complex ligands used in catalysis.
• Fluorine Chemistry Studies: An important substrate for academic and industrial research exploring new fluorination reactions and the properties of fluorinated aromatics.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for client-specific molecule construction and scale-up projects.

Basic Information

Product Name	2-Fluoro-6-(4-Chlorophenylthio)Benzonitrile
CAS No.	175204-12-3
Molecular Formula	C13H7ClFNS
Molecular Weight	263.72 g/mol
Synonyms	2-Fluoro-6-[(4-chlorophenyl)thio]benzonitrile; 6-Fluoro-2-[(4-chlorophenyl)thio]benzonitrile; 2-Fluoro-6-(4-chlorophenylsulfanyl)benzonitrile; 2-Fluoro-6-(p-chlorophenylthio)benzonitrile; Benzonitrile, 2-fluoro-6-[(4-chlorophenyl)thio]-; 175204-12-3; 4-Chlorophenyl 2-cyano-3-fluorophenyl sulfide
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-(4-Chlorophenylthio)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.