Description

2-Fluoro-6-(4-Methylphenylthio)Benzonitrile is a specialized fluorinated aromatic nitrile derivative featuring a thioether linkage. This compound matters as a high-value pharmaceutical intermediate and key building block in advanced organic synthesis, enabling the construction of complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers due to its conjugated system and fluorine substitution.
• Chemical Biology Probe Synthesis: Utilized as a scaffold for developing molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales, from gram to kilogram quantities.

Basic Information

Product Name	2-Fluoro-6-(4-Methylphenylthio)Benzonitrile
CAS No.	175204-11-2
Molecular Formula	C14H10FNS
Molecular Weight	243.30 g/mol
Synonyms	2-Fluoro-6-[(4-methylphenyl)thio]benzonitrile; 6-Fluoro-2-[(4-methylphenyl)thio]benzonitrile; Benzonitrile, 2-fluoro-6-[(4-methylphenyl)thio]-; 2-Fluoro-6-(p-tolylthio)benzonitrile; 2-Fluoro-6-(4-methylbenzenethiol)benzonitrile; 2-Fluoro-6-(4-tolylthio)benzonitrile; 175204-11-2; AKOS005258155
EINECS	Contact for details

Quality Control

Our 2-Fluoro-6-(4-Methylphenylthio)Benzonitrile is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be kept under an inert atmosphere for long-term storage to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.