Description

2-Fluoro-6-(4-Chlorobenzyloxy)Benzonitrile is a high-value, multi-functional aromatic nitrile building block used in advanced organic synthesis. Its molecular structure, featuring both fluoro and chlorobenzyloxy substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced herbicides, fungicides, and insecticides, where the fluorine atom can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Used in academic and industrial research to create novel ligands for transition metal catalysis or as a core structure in functional materials.
• Chemical Biology Probe Synthesis: Employed in the construction of molecular probes for studying enzyme function and biological pathways due to its ability to act as a bioisostere.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns.

Basic Information

Product Name	2-Fluoro-6-(4-Chlorobenzyloxy)Benzonitrile
CAS No.	175204-10-1
Molecular Formula	C14H9ClFNO
Molecular Weight	261.68 g/mol
Synonyms	2-Fluoro-6-[(4-chlorophenyl)methoxy]benzonitrile; 6-[(4-Chlorobenzyl)oxy]-2-fluorobenzonitrile; Benzonitrile, 2-fluoro-6-[(4-chlorophenyl)methoxy]-; 2-Fluoro-6-(4-chlorobenzyloxy)phenyl cyanide; 4-Chlorobenzyl 2-cyano-3-fluorophenyl ether; 175204-10-1; FCB Building Block
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-6-(4-Chlorobenzyloxy)Benzonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard research-grade material typically meets a high purity specification suitable for advanced synthetic applications. A detailed Certificate of Analysis (COA) documenting batch-specific results for assay, related substances, and identification is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Store away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.