Description

3,5-Bis(Trifluoromethyl)Cinnamonitrile is a high-value, fluorinated aromatic nitrile building block characterized by its electron-deficient aromatic ring system. This compound matters for its role as a critical intermediate in the synthesis of advanced pharmaceutical agents and agrochemicals, where the introduction of trifluoromethyl groups is known to enhance metabolic stability, lipophilicity, and bioavailability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the CF3 groups.
• Material Science: Precursor for functionalized monomers and ligands used in catalysis and advanced polymer systems.
• Organic Synthesis & Research: Versatile reagent for Suzuki-Miyaura and other cross-coupling reactions to create biaryl structures.
• Ligand Design: Used in the preparation of specialized ligands for transition metal catalysis.
• Fluorine Chemistry Studies: Valuable compound for academic and industrial research into the effects of polyfluorination on chemical reactivity and physical properties.

Basic Information

Product Name	3,5-Bis(Trifluoromethyl)Cinnamonitrile
CAS No.	175136-63-7
Molecular Formula	C12H5F6N
Molecular Weight	277.17 g/mol
Synonyms	(E)-3-[3,5-Bis(trifluoromethyl)phenyl]acrylonitrile; 3,5-Bis(trifluoromethyl)cinnamomitrile; 3-(3,5-Bis(trifluoromethyl)phenyl)-2-propenenitrile; (E)-3-(3,5-Bis(trifluoromethyl)phenyl)prop-2-enenitrile; 2-Propenenitrile, 3-[3,5-bis(trifluoromethyl)phenyl]-; 3,5-Bis(trifluoromethyl)trans-cinnamonitrile
EINECS	Contact for details

Quality Control

Our 3,5-Bis(Trifluoromethyl)Cinnamonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.