Description

(E)-4-Hydroxytamoxifen CAS NO 174592-47-3 is a potent and selective estrogen receptor modulator (SERM) and a major active metabolite of the breast cancer drug Tamoxifen. This compound is a critical reference standard and a key intermediate in pharmaceutical research and development. It is essential for researchers and manufacturers in the fields of oncology, endocrinology, and drug metabolism studies who require high-purity bioactive compounds for analytical and synthetic applications.

Application

• Pharmaceutical Reference Standard: Used as a primary standard for the quality control and assay validation of Tamoxifen and its metabolites in drug formulations.
• Biochemical Research: Serves as a crucial tool for studying estrogen receptor (ER) binding affinity, antagonist activity, and the mechanisms of SERMs in cell-based assays.
• Metabolite Studies: Employed in pharmacokinetic and pharmacodynamic research to understand the biotransformation and activity profile of Tamoxifen.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and development of novel SERM-based therapeutic agents.
• In Vitro Diagnostics: Applied in the development of diagnostic kits and assays for monitoring Tamoxifen therapy in patients.

Basic Information

Product Name	(E)-4-Hydroxytamoxifen
CAS No.	174592-47-3
Molecular Formula	C26H29NO2
Molecular Weight	387.52 g/mol
Synonyms	4-Hydroxytamoxifen; (Z)-4-Hydroxytamoxifen (Isomer); Afimoxifene; ICI 79280; Metabolite BX; Endoxifen; trans-4-Hydroxytamoxifen; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenylbut-1-ene
EINECS	Contact for details

Quality Control

Our (E)-4-Hydroxytamoxifen is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to the highest standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.