Description

3-Fluoro-4-Hydroxy-5-Iodobenzonitrile is a versatile halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique substitution pattern, featuring fluorine, iodine, and a phenolic hydroxyl group, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of advanced organic electronic materials, liquid crystals, and polymers.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira).
• Fluorine Chemistry Studies: Used as a model compound for investigating the effects of fluorine substitution on aromatic systems and hydrogen bonding.

Basic Information

Product Name	3-Fluoro-4-Hydroxy-5-Iodobenzonitrile
CAS No.	173900-33-9
Molecular Formula	C7H3FINO
Molecular Weight	262.99 g/mol
Synonyms	5-Iodo-3-fluoro-4-hydroxybenzonitrile; 4-Cyano-2-fluoro-5-iodophenol; 3-Fluoro-4-hydroxy-5-iodobenzonitrile; 2-Fluoro-5-iodo-4-hydroxybenzonitrile; Benzonitrile, 3-fluoro-4-hydroxy-5-iodo-; 5-Iodo-4-hydroxy-3-fluorobenzonitrile; 4-Hydroxy-3-fluoro-5-iodobenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Hydroxy-5-Iodobenzonitrile is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.