Description

Thiocoraline CAS NO 173046-02-1 is a potent, naturally occurring bisintercalator depsipeptide antibiotic isolated from marine actinomycetes. This compound matters for its significant biological activity, particularly as a potent inhibitor of DNA and RNA polymerases, which makes it a valuable tool in biochemical research and a candidate for drug discovery programs. It is primarily needed by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on oncology, antimicrobial development, and molecular biology.

Application

• Biochemical Research: Used as a specific molecular probe to study DNA replication, transcription mechanisms, and polymerase enzyme function.
• Anticancer Agent Screening: Serves as a reference compound or lead molecule in the discovery and evaluation of novel chemotherapeutic agents due to its cytotoxic properties.
• Antimicrobial Research: Investigated for its activity against Gram-positive bacteria, providing a scaffold for developing new antibiotic classes.
• Mechanistic Studies: Employed in studies of bisintercalation and its effects on nucleic acid structure and function.
• Pharmaceutical Development: Acts as a key intermediate or reference standard in the synthesis and quality control of novel therapeutic agents.
• Academic Research: Utilized in university and institutional labs for fundamental research in chemical biology, marine natural products, and pharmacology.

Basic Information

Product Name	Thiocoraline
CAS No.	173046-02-1
Molecular Formula	C₅₈H₈₄N₁₂O₁₈S₄
Molecular Weight	1381.6 g/mol
Synonyms	Thiocoraline; Antibiotic U-58766; U-58766; L-Valine, L-threonyl-L-seryl-L-α-asparaginyl-L-seryl-glycyl-L-α-glutamyl-L-seryl-L-α-glutaminyl-L-seryl-L-α-glutaminyl-L-seryl-L-α-glutaminyl-L-seryl-, cyclic (8→1)-lactone, 38-carboxy-45-(3-hydroxy-4-methoxyphenyl)-27,33-dimethyl-16,22,28,34-tetrathia-4,7,10,13,19,24,30,37,40,43,46-undecaoxo-3,6,9,12,18,23,29,36,39,42,45-undecaazapentacyclo[24.22.2.2¹⁵,¹⁸.0²,¹⁴.0²⁰,³²]octatetraconta-1(43),15,17,20(32),21,25,31,34,41,44-decaene-26-carboxylic acid
EINECS	Contact for details

Quality Control

Our Thiocoraline is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with the specifications agreed upon with the customer.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere or with desiccant to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum conforms to reference
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.