Description

3-Fluoro-4-Methylbenzonitrile is a versatile fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring both an electron-withdrawing nitrile group and a fluorine substituent on a methylated benzene ring, makes it a critical intermediate for introducing specific functionalities into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors, CNS-active compounds, and other fluorinated drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs), improving performance and durability.
• Polymer & Resin Modifier: Incorporated into specialty polymers to alter thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination for creating complex biaryl systems.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and developing novel synthetic methodologies.

Basic Information

Product Name	3-Fluoro-4-Methylbenzonitrile
CAS No.	170572-49-3
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	4-Cyano-2-fluorotoluene; 2-Fluoro-4-cyanotoluene; 3-Fluoro-p-tolunitrile; 4-Methyl-3-fluorobenzonitrile; Benzonitrile, 3-fluoro-4-methyl-; 3-Fluoro-4-methylbenzenecarbonitrile; 2-Fluoro-4-methylbenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-Methylbenzonitrile is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide full traceability and detailed Certificates of Analysis (COA) for every shipment, supporting your quality assurance and regulatory compliance needs in cGMP and ISO environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.