Description

1,3-Difluoro-2-Methyl-5-Nitrobenzene is a high-purity fluorinated nitroaromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for molecules requiring a difluoromethylbenzene core.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the fluorine atoms enhance biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Dye and Pigment Intermediate: Employed in the synthesis of complex dyes and pigments, where the nitro and fluorine groups influence color and fastness properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and fluoro groups make it reactive in SNAr reactions for introducing various nucleophiles.

Basic Information

Product Name	1,3-Difluoro-2-Methyl-5-Nitrobenzene
CAS No.	170572-48-2
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2-Methyl-1,3-difluoro-5-nitrobenzene; 1,3-Difluoro-2-methyl-5-nitrobenzene; 2,6-Difluoro-3-nitrotoluene; 3-Nitro-2,6-difluorotoluene; 5-Nitro-2,6-difluorotoluene; Benzene, 1,3-difluoro-2-methyl-5-nitro-; Toluene, 3-nitro-2,6-difluoro-
EINECS	Contact for details

Quality Control

Our 1,3-Difluoro-2-Methyl-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay and impurity profiles. Our quality commitment supports compliance in cGMP and ISO 9001 environments for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.