Description

4-Chloro-2,3-Difluoronitrobenzene is a versatile and high-purity halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an essential intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought by R&D chemists and process development scientists for the synthesis of active pharmaceutical ingredients (APIs), crop protection agents, and specialty dyes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those containing fluorinated and chlorinated aromatic rings.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the difluoro and chloro substituents enhance biological activity.
• Material Science: Building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Dye & Pigment Manufacturing: Intermediate in the production of complex, high-performance colorants and pigments.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Aromatic Substitution: The activated nitro and halogen groups make it an excellent substrate for displacement reactions with various nucleophiles.

Basic Information

Product Name	4-Chloro-2,3-Difluoronitrobenzene
CAS No.	169468-80-8
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	1-Chloro-4,5-difluoro-2-nitrobenzene; 4,5-Difluoro-2-nitrochlorobenzene; 2,3-Difluoro-4-chloronitrobenzene; Benzene, 1-chloro-4,5-difluoro-2-nitro-; 4-Chloro-2,3-difluoro-1-nitrobenzene; 2-Nitro-4,5-difluorochlorobenzene; 4-Chloro-2,3-difluoronitrobenzene (primary name)
EINECS	Contact for details

Quality Control

Our 4-Chloro-2,3-Difluoronitrobenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, identity confirmation by FT-IR and NMR, and precise quantification of impurities. A Certificate of Analysis (COA) detailing all specifications is available for every batch upon request, supporting your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.