Description

Nebivolol Hcl CAS NO 169293-50-9 is a high-purity active pharmaceutical ingredient (API) and a highly selective β-1 adrenergic receptor antagonist. It is a critical component in the formulation of cardiovascular medications, primarily used to manage hypertension and heart failure. This compound is essential for pharmaceutical manufacturers and research institutions engaged in the development and production of advanced cardiology drugs, requiring a reliable supply of material that meets stringent pharmacopeial standards.

Application

• Pharmaceutical API: Primary active ingredient in antihypertensive and anti-anginal medication formulations.
• Cardiovascular Drug Synthesis: Key intermediate in the synthesis of finished dosage forms such as tablets and capsules.
• Clinical Research: Reference standard and material for pharmacological studies and clinical trials.
• Analytical Development: Used as a certified reference material (CRM) for method development and validation in quality control laboratories.
• Generic Drug Manufacturing: Sourcing for the production of bioequivalent generic versions of branded nebivolol medications.
• Preclinical Studies: Utilized in animal models to study hemodynamic effects and receptor selectivity.

Basic Information

Product Name	Nebivolol Hcl
CAS No.	169293-50-9
Molecular Formula	C22H25F2NO4 • HCl
Molecular Weight	441.90 g/mol (as hydrochloride)
Synonyms	Nebivolol Hydrochloride; (αR,α'R,2R,2'S)-α,α'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] Hydrochloride; Bystolic (brand name); R 65-824; R-65824; UNII-5V5IOJ8338; Nebilet; Lobivon
EINECS	Contact for details

Quality Control

Our Nebivolol Hcl is manufactured under strict quality management systems, targeting compliance with major pharmacopeial standards such as USP and EP. Each batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and regulatory support for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.