Description

1,3-Dioxolan-2-One, 4-(Trifluoromethyl)-, (+)- is a high-purity, chiral cyclic carbonate derivative, distinguished by its trifluoromethyl group and specific optical rotation. This compound is a critical chiral building block and fluorinated intermediate, offering unique reactivity and physicochemical properties for advanced synthesis. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorinated motifs and chiral centers into complex molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced, fluorinated pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved performance and stability.
• Polymer Chemistry: Acts as a monomer or modifying agent for synthesizing specialty polymers with tailored properties like solubility, thermal stability, and surface characteristics.
• Asymmetric Catalysis & Ligand Synthesis: Employed in the preparation of chiral ligands and catalysts for enantioselective transformations in fine chemical manufacturing.
• Organic Synthesis & Process R&D: A versatile reagent for introducing the trifluoromethyl-oxazolidinone moiety in complex organic molecules during route scouting and optimization.

Basic Information

Product Name	1,3-Dioxolan-2-One, 4-(Trifluoromethyl)-, (+)-
CAS No.	167951-81-7
Molecular Formula	C4H3F3O3
Molecular Weight	156.06 g/mol
Synonyms	(+)-4-(Trifluoromethyl)-1,3-dioxolan-2-one; (R)-(+)-4-(Trifluoromethyl)-1,3-dioxolan-2-one; (4R)-4-(Trifluoromethyl)-1,3-dioxolan-2-one; (R)-4-(Trifluoromethyl)-1,3-dioxolan-2-one; Trifluoromethyl ethylene carbonate, (+)-; Optically active 4-Trifluoromethyl-1,3-dioxolan-2-one
EINECS	Contact for details

Quality Control

Our 1,3-Dioxolan-2-One, 4-(Trifluoromethyl)-, (+)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) and chemical purity determination, to ensure it meets the stringent requirements for advanced research and GMP-grade synthesis. A detailed Certificate of Analysis (COA) with full specifications, including results for assay, optical rotation, and impurity profiles, is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Optical Rotation [α]D20	+15.0° to +18.0° (c=1 in CHCl3)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.