Description

4,5-Difluoro-2-Nitrobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and nitrile groups on a difluorinated benzene ring, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients, including potential drug candidates and crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides where the difluoro-nitrobenzonitrile moiety imparts desirable biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating advanced organic materials, such as liquid crystals, polymers, and organic semiconductors, where fluorine atoms enhance material properties.
• Chemical Biology & Proteomics: Employed in the design and synthesis of chemical probes, tags, and linkers for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a fluorinated, functionalized aromatic core.

Basic Information

Product Name	4,5-Difluoro-2-Nitrobenzonitrile
CAS No.	165671-05-6
Molecular Formula	C7H2F2N2O2
Molecular Weight	184.10 g/mol
Synonyms	2-Nitro-4,5-difluorobenzonitrile; 4,5-Difluoro-2-nitrobenzenecarbonitrile; Benzonitrile, 4,5-difluoro-2-nitro-; 165671-05-6; 4,5-Difluoronitrobenzonitrile; 2-Cyano-4,5-difluoronitrobenzene
EINECS	Contact for details

Quality Control

Our 4,5-Difluoro-2-Nitrobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications in GMP and ISO-compliant environments, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is light-sensitive (store away from light) and should be handled under inert atmosphere for long-term storage to prevent degradation. Keep away from strong acids/bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.