Description

Mecilizine CAS NO 163837-50-1 is a high-purity pharmaceutical intermediate and active ingredient belonging to the piperazine derivative class. This compound is critical for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily required by manufacturers in the pharmaceutical industry for the development and production of antiemetic and antihistamine medications.

Application

• Pharmaceutical Active Ingredient (API): Primary use as the key active component in prescription and over-the-counter medications for motion sickness and vertigo.
• Antiemetic Formulations: Essential in the synthesis of drugs designed to prevent and treat nausea and vomiting.
• Antihistamine Production: Used in the manufacture of H1-receptor antagonist medications for allergy relief.
• Vestibular Disorder Treatments: A crucial intermediate for medications targeting inner ear balance disorders like Meniere's disease.
• Research & Development: Serves as a reference standard and building block in pharmacological and medicinal chemistry research.
• Generic Drug Manufacturing: A vital raw material for companies producing generic versions of branded antiemetic drugs.

Basic Information

Product Name	Mecilizine
CAS No.	163837-50-1
Molecular Formula	C25H27ClN2
Molecular Weight	390.95 g/mol
Synonyms	Meclizine; Meclozine; 1-(4-Chlorobenzhydryl)-4-(3-methylbenzyl)piperazine; Postafen; Bonine; Antivert; Dramamine Less Drowsy; Calmonal; Itinerol; Piplizine; Histametizyne; CB-1678
EINECS	Contact for details

Quality Control

Our Mecilizine is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for assay and related substances, to ensure compliance with in-house specifications and customer requirements. A Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single unknown impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.